LY2183240

• Catalog No.: L9044
• CAS Number: 874902-19-9
• M. F.: C17H17N5O
• M. W.: 307.34978
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1H-1,2,3,4-tetrazole-1-carboxamide
• IUPAC Traditional name: N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1,2,3,4-tetrazole-1-carboxamide
• Synonyms: 1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-; 5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide

DATABASE IDS

• MDL Number: MFCD08703123
• CAS Number: 874902-19-9

PROPERTIES

• Empirical Formula (Hill Notation): C17H17N5O
• Purity: ≥98% (HPLC)
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Regioisomer 1-5 of LY2183240 is a potent inhibitor of anandamide uptake (IC50= 15 nM). The compound inhibits FAAH (IC50=2.1 nM) and some other brain serine proteases. After systemic administration to rodents, LY2182340 elevates brain anandamide levels and shows efficacy in a rodent model of persistent pain (ED50=1.37 mg/kg). Regioisomer 2-5 of LY2183240 is less active. The compound is more potent than N-(4-Hydroxyphenyl)-arachidonylamide (AM-404), which inhibits anandamide transport at IC50=1mM.

Description (简体中文)

Biochem/physiol Actions
Regioisomer 1-5 of LY2183240 is a potent inhibitor of anandamide uptake (IC50= 15 nM). The compound inhibits FAAH (IC50=2.1 nM) and some other brain serine proteases. After systemic administration to rodents, LY2182340 elevates brain anandamide levels and shows efficacy in a rodent model of persistent pain (ED50=1.37 mg/kg). Regioisomer 2-5 of LY2183240 is less active. The compound is more potent than N-(4-Hydroxyphenyl)-arachidonylamide (AM-404), which inhibits anandamide transport at IC50=1mM.