GW583340 dihydrochloride

• Catalog No.: G3545
• M. F.: C28H27Cl3FN5O3S2
• M. W.: 671.0330832
• Purity: ≥97% (HPLC)

SYNONYMS

• IUPAC name: N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(2-{[(2-methanesulfonylethyl)amino]methyl}-1,3-thiazol-4-yl)quinazolin-4-amine dihydrochloride
• IUPAC Traditional name: N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(2-{[(2-methanesulfonylethyl)amino]methyl}-1,3-thiazol-4-yl)quinazolin-4-amine dihydrochloride
• Synonyms: 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride

DATABASE IDS

• MDL Number: MFCD07370137
• PubChem SID: 24895131

PROPERTIES

• Empirical Formula (Hill Notation): C28H25ClFN5O3S2 · 2HCl
• Purity: ≥97% (HPLC)
• Apperance: solid
• Melting Point: 259.8-262.4 °C(lit.)
• Solubility: DMSO: soluble9 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC50= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active.
Legal Information
Sold for research purposes under agreement from Glaxo-Smith-Kline

Description (简体中文)

Biochem/physiol Actions
Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC50= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active.
Legal Information
Sold for research purposes under agreement from Glaxo-Smith-Kline