TPBM

• Catalog No.: T5202
• CAS Number: 6466-43-9
• M. F.: C15H16N4O2S
• M. W.: 316.37814
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 8-[(benzylsulfanyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC Traditional name: 8-[(benzylsulfanyl)methyl]-1,3-dimethyl-7H-purine-2,6-dione
• Synonyms: Theophylline, 8-[(benzylthio)methyl]; 8-Benzylsulfanylmethyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione; 8-[(Benzylthio)methyl]theophylline

DATABASE IDS

• MDL Number: MFCD11114397
• CAS Number: 6466-43-9

PROPERTIES

• Empirical Formula (Hill Notation): C15H16N4O2S
• Purity: ≥98% (HPLC)
• Apperance: white to off-white solid
• Solubility: DMSO: >5 mg/mL
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
TPBM is a potent inhibitor of estrogen receptor α via blocking ERα binding to consensus estrogen response element (cERE) DNA. Estrogen receptor α (ERα) plays an important role in several human cancers. Current ERα antagonists bind in the receptor ligand binding pocket and compete for binding with estrogenic ligands. TPBM instead inhibits ERα via binding to consensus estrogen response element (cERE) DNA. TPBM is not toxic to cells and does not effect estrogen-independent cell growth. TPBM does not act by chelating the zinc in ERs zinc fingers and differs from known ERα inhibitors.

Description (简体中文)

Biochem/physiol Actions
TPBM is a potent inhibitor of estrogen receptor α via blocking ERα binding to consensus estrogen response element (cERE) DNA. Estrogen receptor α (ERα) plays an important role in several human cancers. Current ERα antagonists bind in the receptor ligand binding pocket and compete for binding with estrogenic ligands. TPBM instead inhibits ERα via binding to consensus estrogen response element (cERE) DNA. TPBM is not toxic to cells and does not effect estrogen-independent cell growth. TPBM does not act by chelating the zinc in ERs zinc fingers and differs from known ERα inhibitors.