Leptomycin A

• Catalog No.: L6417
• CAS Number: 87081-36-5
• M. F.: C32H46O6
• M. W.: 526.70404
• Purity: ~95% (HPLC)

SYNONYMS

• Title: Leptomycin A 来源于链霉菌 属
• IUPAC name: 6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• IUPAC Traditional name: 6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
• Synonyms: 19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid; Jildamycin

DATABASE IDS

• MDL Number: MFCD01711669
• CAS Number: 87081-36-5

PROPERTIES

• Biological Source: from Streptomyces sp.
• Empirical Formula (Hill Notation): C32H46O6
• Purity: ~95% (HPLC)
• Shipped in: dry ice
• Apperance: methanol solution
• European Hazard Symbols: Flammable (F)
• European Hazard Symbols: Toxic (T)
• RID/ADR: UN 1230 3/PG 2
• Risk Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 7-16-36/37-45
• Storage Temperature: -20°C
• Hazard Class: 3
• UN Number: 1230
• Packing Group: 2
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
Leptomycins are antifungal antibiotics with unique unsaturated, branched-chain fatty acid structures.1, The physiochemical and biological properties of Leptomycins A and B are very similar.2, Both are considered to be specific inhibitors of nuclear export. The suggested inhibition mechanism involves the direct binding of leptomycins to CRM1 (Exportin-1), which is the main nuclear export protein. This blocks the binding of CRM1 to proteins containing a nuclear export signal (NES),3,4 and therefore prevents their export from the nucleus. Although more research on nuclear export inhibition has been performed using Leptomycin B, it has been shown that Leptomycin A has similar effects and can induce, for example, nuclear accumulation of wild-type ERK5.5Leptomycin A is also active against Schizosaccaromyces pombe and Mucor rouxianus.2

Description (简体中文)

Biochem/physiol Actions
Leptomycins are antifungal antibiotics with unique unsaturated, branched-chain fatty acid structures.1, The physiochemical and biological properties of Leptomycins A and B are very similar.2, Both are considered to be specific inhibitors of nuclear export. The suggested inhibition mechanism involves the direct binding of leptomycins to CRM1 (Exportin-1), which is the main nuclear export protein. This blocks the binding of CRM1 to proteins containing a nuclear export signal (NES),3,4 and therefore prevents their export from the nucleus. Although more research on nuclear export inhibition has been performed using Leptomycin B, it has been shown that Leptomycin A has similar effects and can induce, for example, nuclear accumulation of wild-type ERK5.5Leptomycin A is also active against Schizosaccaromyces pombe and Mucor rouxianus.2