Celastrol

• Catalog No.: C0869
• CAS Number: 34157-83-0
• M. F.: C29H38O4
• M. W.: 450.60962
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
• IUPAC Traditional name: triterpene
• Synonyms: 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid; Tripterin

DATABASE IDS

• MDL Number: MFCD03424073
• CAS Number: 34157-83-0

PROPERTIES

• Empirical Formula (Hill Notation): C29H38O4
• Purity: ≥98% (HPLC)
• Apperance: red solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• Safety Statements: 45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).

Description (简体中文)

Biochem/physiol Actions
Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).