Thiolutin

• Catalog No.: T3450
• CAS Number: 87-11-6
• M. F.: C9H10N2O2S2
• M. W.: 242.3179
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: N-{4-methyl-5-oxo-4H,5H-[1,2]dithiolo[4,3-b]pyrrol-6-yl}propanamide
• IUPAC Traditional name: aureothricin
• Synonyms: N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-B]Pyrrol-6-yl); Aureothricin; Farcinicin; Propiopyvothine

DATABASE IDS

• MDL Number: MFCD07370147
• CAS Number: 87-11-6

PROPERTIES

• Biological Source: from Streptomyces luteosporeus
• Empirical Formula (Hill Notation): C8H8N2O2S2
• Purity: ≥95% (HPLC)
• Shipped in: wet ice
• Solubility: DMSO: soluble5 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P264-P301 + P310
• RID/ADR: UN 2811 6.1/PG 2
• Risk Statements: 28
• RTECS: JP1355000
• Safety Statements: 45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.

Description (简体中文)

Biochem/physiol Actions
Sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.