Raltitrexed monohydrate

• Catalog No.: R9156
• M. F.: C21H24N4O7S
• M. W.: 476.50286
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-[(5-{methyl[(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid hydrate
• IUPAC Traditional name: (2S)-2-[(5-{methyl[(2-methyl-4-oxo-3H-quinazolin-6-yl)methyl]amino}thiophen-2-yl)formamido]pentanedioic acid hydrate
• Synonyms: ZD-1694; ICI-D-1694; L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)- monohydrate

DATABASE IDS

• MDL Number: MFCD12828867

PROPERTIES

• Empirical Formula (Hill Notation): C21H22N4O6S · H2O
• Purity: ≥98% (HPLC)
• Apperance: off-white to light yellow solid
• Solubility: H2O: ≥10 mg/mL
• Solubility: DMSO: ≥40 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H360
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P201-P264-P301 + P310-P308 + P313
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 61-25
• Safety Statements: 53-45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

Description (简体中文)

Biochem/physiol Actions
Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.