TUG-424

• Catalog No.: T6829
• CAS Number: 1082058-99-8
• M. F.: C18H16O2
• M. W.: 264.31844
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-{4-[2-(2-methylphenyl)ethynyl]phenyl}propanoic acid
• IUPAC Traditional name: 3-{4-[2-(2-methylphenyl)ethynyl]phenyl}propanoic acid
• Synonyms: 3-(4-(o-Tolylethynyl)phenyl)propanoic acid

DATABASE IDS

• CAS Number: 1082058-99-8
• MDL Number: MFCD12912449

PROPERTIES

• Empirical Formula (Hill Notation): C18H16O2
• Purity: ≥98% (HPLC)
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H319-H410
• European Hazard Symbols: Irritant (Xi)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P273-P305 + P351 + P338-P501
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 36-50/53
• Safety Statements: 26-60-61
• Storage Temperature: 2-8°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.

Description (简体中文)

Biochem/physiol Actions
TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.