Rubitecan

• Catalog No.: R3655
• CAS Number: 91421-42-0
• M. F.: C20H15N3O6
• M. W.: 393.3496

SYNONYMS

• IUPAC name: (19S)-19-ethyl-19-hydroxy-8-nitro-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• IUPAC Traditional name: 9-nitrocamptothecin
• Synonyms: 9-nitrocamptothecin

DATABASE IDS

• MDL Number: MFCD06656294
• CAS Number: 91421-42-0

PROPERTIES

• Empirical Formula (Hill Notation): C20H15N3O6
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: UQ0493300
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Topoisomerase I inhibitor. Rubitecan induces protein- linked DNA single strand breaks, blocking DNA and RNA synthesis in dividing cells. This mode of action makes rubitecan a potential chemotherapeutic agent, and it has been used with some success against refractory pancreatic cancer.1

Description (简体中文)

Biochem/physiol Actions
Topoisomerase I inhibitor. Rubitecan induces protein- linked DNA single strand breaks, blocking DNA and RNA synthesis in dividing cells. This mode of action makes rubitecan a potential chemotherapeutic agent, and it has been used with some success against refractory pancreatic cancer.1