BAY 61-3606 hydrochloride hydrate

• Catalog No.: B9685
• M. F.: C20H21ClN6O4
• M. W.: 444.87154
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-{[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}pyridine-3-carboxamide hydrate hydrochloride
• IUPAC Traditional name: 2-{[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}pyridine-3-carboxamide hydrate hydrochloride
• Synonyms: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide hydrochloride

PROPERTIES

• Empirical Formula (Hill Notation): C20H18N6O3 · xHCl · yH2O
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: H2O: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Spleen tyrosine kinase (Syk) inhibitor; anti-inflammatory. Syk plays a major role in inflammation pathways via receptors for the Fc portion of immunoglobulins, as well as B cell signaling. It is orally active, potent (Ki 7.5 nM), and highly selective for Syk vs other kinases (Lyn, Fyn, Src, Itk, Btk; Ki′s).

Description (简体中文)

Biochem/physiol Actions
Spleen tyrosine kinase (Syk) inhibitor; anti-inflammatory. Syk plays a major role in inflammation pathways via receptors for the Fc portion of immunoglobulins, as well as B cell signaling. It is orally active, potent (Ki 7.5 nM), and highly selective for Syk vs other kinases (Lyn, Fyn, Src, Itk, Btk; Ki′s).