Daptomycin

• Catalog No.: D2446
• CAS Number: 103060-53-3
• M. F.: C72H101N17O26
• M. W.: 1620.67064
• Purity: ≥90% (HPLC)

SYNONYMS

• IUPAC name: (3S)-3-{[(3S,6S,9R,15S,18R,21S,24R,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]carbamoyl}-3-[(2R)-3-carbamoyl-2-[(2S)-2-decanamido-3-(1H-indol-3-yl)propanamido]propanamido]propanoic acid
• IUPAC Traditional name: (3S)-3-{[(3S,6S,9R,15S,18R,21S,24R,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]carbamoyl}-3-[(2R)-3-carbamoyl-2-[(2S)-2-decanamido-3-(1H-indol-3-yl)propanamido]propanamido]propanoic acid
• Synonyms: Dapcin

DATABASE IDS

• CAS Number: 103060-53-3

PROPERTIES

• Empirical Formula (Hill Notation): C72H101N17O26
• Purity: ≥90% (HPLC)
• Solubility: DMSO: soluble
• Solubility: ethanol: soluble
• Solubility: methanol: soluble
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Cyclic lipopeptide antibiotic effective against gram-positive bacteria. Derived from a fermentation product of Streptomyces sp. Its distinct mechanism of action, disrupting plamsa membrane function, makes it useful against resistant bacteria. Potential therapy for Staphylococcus aureus infections, including MRSA (methicillin-resistant Staphylococcus aureus).
Daptomycin disrupts plasma membrane function, which makes it useful against resistant bacteria. It is thought to cause rapid depolarization thereby inhibiting protein, DNA and RNA synthesis.
Application
Daptomycin is a cyclic lipopeptide antibiotic effective against gram-positive bacteria. It is derived from a fermentation product of Streptomyces sp. It is useful against resistant bacteria. It is a potential therapy for Staphylococcus aureus infections1, including MRSA (methicillin-resistant Staphylococcus aureus). It has also been studied as a potential therapy for Streptococcus pneumoniae infections 2. It has been used to study the impact of sarA on daptomycin susceptibility of Staphylococcus aureus.3

Description (简体中文)

Biochem/physiol Actions
Cyclic lipopeptide antibiotic effective against gram-positive bacteria. Derived from a fermentation product of Streptomyces sp. Its distinct mechanism of action, disrupting plamsa membrane function, makes it useful against resistant bacteria. Potential therapy for Staphylococcus aureus infections, including MRSA (methicillin-resistant Staphylococcus aureus).
Daptomycin disrupts plasma membrane function, which makes it useful against resistant bacteria. It is thought to cause rapid depolarization thereby inhibiting protein, DNA and RNA synthesis.
Application
Daptomycin is a cyclic lipopeptide antibiotic effective against gram-positive bacteria. It is derived from a fermentation product of Streptomyces sp. It is useful against resistant bacteria. It is a potential therapy for Staphylococcus aureus infections1, including MRSA (methicillin-resistant Staphylococcus aureus). It has also been studied as a potential therapy for Streptococcus pneumoniae infections 2. It has been used to study the impact of sarA on daptomycin susceptibility of Staphylococcus aureus.3