RRD-251 hydrochloride

• Catalog No.: R7532
• CAS Number: 72214-67-6
• M. F.: C8H9Cl3N2S
• M. W.: 271.59446
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: {[(2,4-dichlorophenyl)methyl]sulfanyl}methanimidamide hydrochloride
• IUPAC Traditional name: [(2,4-dichlorophenyl)methyl]sulfanylmethanimidamide hydrochloride
• Synonyms: Rb/Raf-1 disruptor 251 hydrochloride; 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride; (2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride; S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride

DATABASE IDS

• CAS Number: 72214-67-6
• MDL Number: MFCD00035047

PROPERTIES

• Empirical Formula (Hill Notation): C8H8Cl2N2S· HCl
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: >2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• Storage Condition: desiccated
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

Description (简体中文)

Biochem/physiol Actions
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.