DCHC

• Catalog No.: D5569
• CAS Number: 302953-06-6
• M. F.: C15H8Cl2O3
• M. W.: 307.12822
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-(2,4-dichlorophenyl)-7-hydroxy-4H-chromen-4-one
• IUPAC Traditional name: 3-(2,4-dichlorophenyl)-7-hydroxychromen-4-one
• Synonyms: 3-(2,4-Dichlorophenyl)-7-hydroxy-4H-chromen-4-one

DATABASE IDS

• CAS Number: 302953-06-6
• MDL Number: MFCD01848896

PROPERTIES

• Empirical Formula (Hill Notation): C15H8Cl2O3
• Purity: ≥98% (HPLC)
• Apperance: yellow solid
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• Safety Statements: 45
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
DCHC is a SIRT1 activator. It increases peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) expression, resulting in mitochondrial biogenesis. DCHC activates SIRT1 at low micromolar concentrations (5-10 μM) and increases SIRT1 activity at 100 μM. It is different from 5,7,4′-T in that it induces the activation of recombinant SIRT1, but does not increase SIRT1 expression.

Description (简体中文)

Biochem/physiol Actions
DCHC is a SIRT1 activator. It increases peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) expression, resulting in mitochondrial biogenesis. DCHC activates SIRT1 at low micromolar concentrations (5-10 μM) and increases SIRT1 activity at 100 μM. It is different from 5,7,4′-T in that it induces the activation of recombinant SIRT1, but does not increase SIRT1 expression.