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LY225910

Catalog No. L2545 Name Sigma Aldrich
CAS Number 133040-77-4 Website http://www.sigmaaldrich.com
M. F. C27H24BrN3O2 Telephone 1-800-521-8956
M. W. 502.40236 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154350

SYNONYMS

IUPAC name
2-[2-(5-bromo-1H-indol-3-yl)ethyl]-3-[3-(propan-2-yloxy)phenyl]-3,4-dihydroquinazolin-4-one
IUPAC Traditional name
2-[2-(5-bromo-1H-indol-3-yl)ethyl]-3-(3-isopropoxyphenyl)quinazolin-4-one
Synonyms
2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy )phenyl]-4-(3H)-quinazolinone

DATABASE IDS

MDL Number MFCD00907856
CAS Number 133040-77-4

PROPERTIES

Empirical Formula (Hill Notation) C27H24BrN3O2
Purity ≥98% (HPLC)
Apperance off-white powder
Flash Point 337 - 405 °C
Flash Point 638.6 - 761 °F
Solubility DMSO: >20 mg/mL
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301-H413
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
GHS Precautionary statements P301 + P310
RID/ADR UN 2811 6.1/PG 3
Risk Statements 22
Storage Temperature 2-8°C
Hazard Class 6.1
UN Number 2811
Packing Group 3
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Cholecystokinin is expressed in the gastrointestinal tract and the central nervous system. Cholecystokinin receptor type 2 (CCK2) is a GPCR that is highly expressed in brain and spinal cord. CCK2 is implicated in many brain processes, including mood, anxiety, and pain, through its modulation of GABA neurotransmission.LY225910 is a potent, selective CCK2 antagonist. LY225910 blocks agonism of CCK2 by CCK-8S, the peptide agonist. LY225910 has been measured in multiple systems, including GABA efflux from cortical cultures, depolarization of spinal cord neurons (via potassium conductance), modulation of excitatory postsynaptic potentials (EPSPs) in nucleus accumbens slices, and enhancement of morphine analgesia.
Description (简体中文)
Biochem/physiol Actions
Cholecystokinin is expressed in the gastrointestinal tract and the central nervous system. Cholecystokinin receptor type 2 (CCK2) is a GPCR that is highly expressed in brain and spinal cord. CCK2 is implicated in many brain processes, including mood, anxiety, and pain, through its modulation of GABA neurotransmission.LY225910 is a potent, selective CCK2 antagonist. LY225910 blocks agonism of CCK2 by CCK-8S, the peptide agonist. LY225910 has been measured in multiple systems, including GABA efflux from cortical cultures, depolarization of spinal cord neurons (via potassium conductance), modulation of excitatory postsynaptic potentials (EPSPs) in nucleus accumbens slices, and enhancement of morphine analgesia.

REFERENCES