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Ara-G hydrate_Molecular_structure_CAS_38819-10-2(anhydrous))
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Ara-G hydrate

Catalog No. A4233 Name Sigma Aldrich
CAS Number 38819-10-2(anhydrous) Website http://www.sigmaaldrich.com
M. F. C10H13N5O5 Telephone 1-800-521-8956
M. W. 283.24072 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154349

SYNONYMS

IUPAC name
2-amino-9-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one
IUPAC Traditional name
2-amino-9-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
Synonyms
9-β-D-Arabinofuranosyl guanine hydrate

DATABASE IDS

CAS Number 38819-10-2(anhydrous)
MDL Number MFCD00065486

PROPERTIES

Empirical Formula (Hill Notation) C10H13N5O5 · xH2O
Purity ≥98% (HPLC)
Apperance solid
Solubility DMSO: >10 mg/mL
Solubility H2O: insoluble
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H315-H319-H335
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 22-36/37/38
RTECS MF8301000
Safety Statements 26
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Application
Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite.
Biochem/physiol Actions
Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.
Description (简体中文)
Application
Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite.
Biochem/physiol Actions
Ara-G is an inducer of apoptosis; inhibitor of DNA synthesis; antineoplastic; and antimetabolite. Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis.

REFERENCES