Imidazolo-oxindole PKR inhibitor C16

• Catalog No.: I9785
• CAS Number: 608512-97-6
• M. F.: C13H8N4OS
• M. W.: 268.29382
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 8-(1H-imidazol-4-ylmethylidene)-6H,7H,8H-[1,3]thiazolo[5,4-e]indol-7-one
• IUPAC Traditional name: 8-(1H-imidazol-4-ylmethylidene)-6H-[1,3]thiazolo[5,4-e]indol-7-one
• Synonyms: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

DATABASE IDS

• MDL Number: MFCD06735404
• CAS Number: 608512-97-6

PROPERTIES

• Empirical Formula (Hill Notation): C13H8N4OS
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Solubility: DMSO: soluble12 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Protect from light and air.
Biochem/physiol Actions
Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.

Description (简体中文)

Other Notes
Protect from light and air.
Biochem/physiol Actions
Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.