KM11060

• Catalog No.: K1519
• CAS Number: 774549-97-2
• M. F.: C19H17Cl2N3O2S
• M. W.: 422.32818
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 7-chloro-4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]quinoline
• IUPAC Traditional name: 7-chloro-4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]quinoline
• Synonyms: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

DATABASE IDS

• CAS Number: 774549-97-2
• MDL Number: MFCD01524977

PROPERTIES

• Empirical Formula (Hill Notation): C19H17Cl2N3O2S
• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• Safety Statements: 45
• Storage Temperature: room temp
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.

Description (English)

Biochem/physiol Actions
KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.