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GW6471

Catalog No. G5045 Name Sigma Aldrich
CAS Number 880635-03-0 Website http://www.sigmaaldrich.com
M. F. C35H36F3N3O4 Telephone 1-800-521-8956
M. W. 619.6732496 Fax
Purity ≥98% (HPLC) Email
Storage desiccated Chembase ID: 154327

SYNONYMS

IUPAC name
N-[(2S)-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-({4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl}amino)propyl]propanamide
IUPAC Traditional name
N-[(2S)-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-({4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl}amino)propyl]propanamide
Synonyms
N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide

DATABASE IDS

CAS Number 880635-03-0
MDL Number MFCD07784503
PubChem SID 24724489

PROPERTIES

Empirical Formula (Hill Notation) C35H36F3N3O4
Purity ≥98% (HPLC)
Apperance off-white to light yellow solid
Solubility DMSO: >10 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H315-H319-H335
European Hazard Symbols Irritant Irritant (Xi)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 36/37/38
Safety Statements 26-36
Storage Condition desiccated
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.
Description (简体中文)
Biochem/physiol Actions
GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.

REFERENCES