GW6471

• Catalog No.: G5045
• CAS Number: 880635-03-0
• M. F.: C35H36F3N3O4
• M. W.: 619.6732496
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: N-[(2S)-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-({4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl}amino)propyl]propanamide
• IUPAC Traditional name: N-[(2S)-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl}-2-({4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl}amino)propyl]propanamide
• Synonyms: N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide

DATABASE IDS

• CAS Number: 880635-03-0
• MDL Number: MFCD07784503
• PubChem SID: 24724489

PROPERTIES

• Empirical Formula (Hill Notation): C35H36F3N3O4
• Purity: ≥98% (HPLC)
• Apperance: off-white to light yellow solid
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.

Description (简体中文)

Biochem/physiol Actions
GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.