IMD-0354

• Catalog No.: I3159
• CAS Number: 978-62-1
• M. F.: C15H8ClF6NO2
• M. W.: 383.6729392
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
• IUPAC Traditional name: N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
• Synonyms: N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide

DATABASE IDS

• PubChem SID: 24724513
• MDL Number: MFCD00218820
• CAS Number: 978-62-1

PROPERTIES

• Empirical Formula (Hill Notation): C15H8ClF6NO2
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Apperance: solid
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Selective IKK-2 inhibitor. Blocks IκBα phosphorylation (IC50 ~ 250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Cardioprotectant, reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes.
Packaging
Light sensitive. Packaged under nitrogen.

Description (简体中文)

Biochem/physiol Actions
Selective IKK-2 inhibitor. Blocks IκBα phosphorylation (IC50 ~ 250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Cardioprotectant, reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes.
包装
Light sensitive. Packaged under nitrogen.