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Chalcone 4 hydrate

Catalog No. C7870 Name Sigma Aldrich
CAS Number 1202866-96-3 Website http://www.sigmaaldrich.com
M. F. C16H15ClO4 Telephone 1-800-521-8956
M. W. 306.7409 Fax
Purity ≥98% (HPLC) Email
Storage protect from light Chembase ID: 154280

SYNONYMS

IUPAC name
1-(4-chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one hydrate
IUPAC Traditional name
1-(4-chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one hydrate
Synonyms
(E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate

DATABASE IDS

CAS Number 1202866-96-3
MDL Number MFCD12912407

PROPERTIES

Empirical Formula (Hill Notation) C16H13ClO3 · xH2O
Purity ≥98% (HPLC)
Apperance yellow solid
Solubility DMSO: >20 mg/mL
GHS Pictograms GHS09
GHS Signal Word Warning
GHS Hazard statements H410
European Hazard Symbols Nature polluting Nature polluting (N)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P273-P501
RID/ADR UN 3077 9/PG 3
Risk Statements 50/53
Safety Statements 60-61
Storage Condition protect from light
Storage Temperature -20°C
Hazard Class 9
UN Number 3077
Packing Group 3
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Chalcone 4 is a potent, selective inhibitor of the chemokine CXCL12 via direct binding. It is also a small molecule anti-ligand (or neutraligand) of CXCR4 and CXCR7. The chemokine CXCL12 (stromal cell-derived factor-1) and its receptors play pivotal roles in inflammatory responses, normal vascular and neuronal development, as well as in infectious diseases and cancer. Chalcone 4 binds to and activates the chemokine receptors CXCR4 and CXCR7 and stimulates a rapid receptor-mediated intracellular calcium mobilization and signaling through a Pertussis toxin sensitive Gi protein. Chalcone 4 potently and selectively inhibits CXCL12 binding to CXCR4 and CXCR7, and consequent CXCL12-evoked calcium cellular responses. Chalcone 4 binds to the chemokine CXCL12, but not to its receptors.
Description (简体中文)
Biochem/physiol Actions
Chalcone 4 is a potent, selective inhibitor of the chemokine CXCL12 via direct binding. It is also a small molecule anti-ligand (or neutraligand) of CXCR4 and CXCR7. The chemokine CXCL12 (stromal cell-derived factor-1) and its receptors play pivotal roles in inflammatory responses, normal vascular and neuronal development, as well as in infectious diseases and cancer. Chalcone 4 binds to and activates the chemokine receptors CXCR4 and CXCR7 and stimulates a rapid receptor-mediated intracellular calcium mobilization and signaling through a Pertussis toxin sensitive Gi protein. Chalcone 4 potently and selectively inhibits CXCL12 binding to CXCR4 and CXCR7, and consequent CXCL12-evoked calcium cellular responses. Chalcone 4 binds to the chemokine CXCL12, but not to its receptors.

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