Tris(2-carboxyethyl)phosphine hydrochloride solution

• Catalog No.: 646547
• CAS Number: 51805-45-9
• M. F.: C9H16ClO6P
• M. W.: 286.646501

SYNONYMS

• Title: 三(2-羧乙基)膦 盐酸盐 溶液
• IUPAC name: 3-[bis(2-carboxyethyl)phosphanyl]propanoic acid hydrochloride
• IUPAC Traditional name: tris(2-carboxyethyl)phosphine hydrochloride
• Synonyms: TCEP

DATABASE IDS

• MDL Number: MFCD00145469
• PubChem SID: 24883469
• CAS Number: 51805-45-9

PROPERTIES

• Concentration: 0.5 M
• Empirical Formula (Hill Notation): C9H15O6P · HCl
• Density: 1.041 g/mL at 25 °C
• pH: 7.0
• Refractive Index: n20/D 1.367
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 36
• Safety Statements: 26
• German water hazard class: 2

DETAILS

Description (English)

Packaging
1, 10×1 mL in ampule
Application
TCEP is an effective reducing agent for protein analysis. As a non-mercaptan reducing agent, it avoids the toxicity inherent in thiol-containing compounds. It is capable of disrupting the botulinum neurotoxin B heavy-chain/light-chain complex that is held together by a single disulfide bond, and that is responsible for endocytosis, and ultimately the toxicity, of the toxin. Since disulfide-coupled subunits are characteristic of many toxins (e.g., ricin, snake venom, and all BoNT serotypes), it may be useful as a rescue prophylactic in cases of toxin administration.1

Description (简体中文)

包装
1, 10×1 mL in ampule
Application
TCEP is an effective reducing agent for protein analysis. As a non-mercaptan reducing agent, it avoids the toxicity inherent in thiol-containing compounds. It is capable of disrupting the botulinum neurotoxin B heavy-chain/light-chain complex that is held together by a single disulfide bond, and that is responsible for endocytosis, and ultimately the toxicity, of the toxin. Since disulfide-coupled subunits are characteristic of many toxins (e.g., ricin, snake venom, and all BoNT serotypes), it may be useful as a rescue prophylactic in cases of toxin administration.1