FTI-276 trifluoroacetate salt

• Catalog No.: F9553
• CAS Number: 170006-72-1(freebase)
• M. F.: C23H28F3N3O5S2
• M. W.: 547.6107296
• Purity: ≥95% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: (2S)-2-[(4-{[(2R)-2-amino-3-sulfanylpropyl]amino}-2-phenylphenyl)formamido]-4-(methylsulfanyl)butanoic acid; trifluoroacetic acid
• IUPAC Traditional name: (2S)-2-[(4-{[(2R)-2-amino-3-sulfanylpropyl]amino}-2-phenylphenyl)formamido]-4-(methylsulfanyl)butanoic acid; trifluoroacetic acid
• Synonyms: N-[4-[2-(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt

DATABASE IDS

• CAS Number: 170006-72-1(freebase)
• MDL Number: MFCD06409253

PROPERTIES

• Empirical Formula (Hill Notation): C21H27N3O3S2 ·C2HF3O2
• Purity: ≥95% (HPLC)
• Shipped in: wet ice
• Apperance: off-white film
• Solubility: H2O: >5 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Condition: desiccated
• Storage Condition: under inert gas
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
FTI-276 is a highly potent RasCAAX peptidomimetic. FTI-276 antagonizes both H and K-Ras oncogenic signaling. It is an inhibitor of farnesyltransferase (Ftase) in vitro with an IC50 of 500 pM and is an anti-cancer agent.

Description (简体中文)

Biochem/physiol Actions
FTI-276 is a highly potent RasCAAX peptidomimetic. FTI-276 antagonizes both H and K-Ras oncogenic signaling. It is an inhibitor of farnesyltransferase (Ftase) in vitro with an IC50 of 500 pM and is an anti-cancer agent.