GGTI 298 trifluoroacetate salt hydrate

• Catalog No.: G5169
• CAS Number: 1217457-86-7(anhydrous)
• M. F.: C29H34F3N3O5S
• M. W.: 593.6575696
• Purity: ≥90% (HPLC)

SYNONYMS

• IUPAC name: trifluoroacetic acid methyl (2S)-2-[(4-{[(2R)-2-amino-3-sulfanylpropyl]amino}-2-(naphthalen-1-yl)phenyl)formamido]-4-methylpentanoate
• IUPAC Traditional name: trifluoroacetic acid methyl (2S)-2-[(4-{[(2R)-2-amino-3-sulfanylpropyl]amino}-2-(naphthalen-1-yl)phenyl)formamido]-4-methylpentanoate
• Synonyms: N-[[4-(2-(R)-Amino-3-mercaptopropyl)amino]-2-naphthylbenzoyl]leucine methyl ester trifluoroacetate salt hydrate

DATABASE IDS

• PubChem SID: 24724490
• MDL Number: MFCD06409252
• CAS Number: 1217457-86-7(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C27H33N3O3S · C2HF3O2 · xH2O
• Impurities: <10% dimer
• Purity: ≥90% (HPLC)
• Gene Information: human ... PGGT1B(5229)
• Apperance: colorless film
• Apperance: lyophilized
• Melting Point: 99.5-100 °C
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.

Description (简体中文)

Biochem/physiol Actions
GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.