Aculeacin A

• Catalog No.: A7603
• CAS Number: 58814-86-1
• M. F.: C50H81N7O16
• M. W.: 1036.21544
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0^9,^1^3]heptacosan-18-yl]hexadecanamide
• IUPAC Traditional name: N-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0^9,^1^3]heptacosan-18-yl]hexadecanamide

DATABASE IDS

• MDL Number: MFCD01674009
• CAS Number: 58814-86-1

PROPERTIES

• Biological Source: from Aspergillus aculeatus
• Empirical Formula (Hill Notation): C50H81N7O16
• Purity: ≥95% (HPLC)
• Shipped in: wet ice
• Solubility: DMSO: soluble10 mg/mL
• Solubility: DMF: soluble
• Solubility: ethanol: soluble
• Solubility: methanol: soluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: AU2980000
• Storage Temperature: -20°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase.
Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β-glucan by selective blockage of β(1→3) glucan synthase.
Application
Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae 1, the inhibition of Candida albicans2, and the morphogenetic transformation of Candida albicans when treated 3.

Description (简体中文)

Biochem/physiol Actions
Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase.
Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β-glucan by selective blockage of β(1→3) glucan synthase.
Application
Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae 1, the inhibition of Candida albicans2, and the morphogenetic transformation of Candida albicans when treated 3.