GGTI-2133

• Catalog No.: G5294
• M. F.: C29H29F3N4O5
• M. W.: 570.5595696
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-({4-[(1H-imidazol-4-ylmethyl)amino]-2-(naphthalen-1-yl)phenyl}formamido)-4-methylpentanoic acid; trifluoroacetic acid
• IUPAC Traditional name: (2S)-2-({4-[(1H-imidazol-4-ylmethyl)amino]-2-(naphthalen-1-yl)phenyl}formamido)-4-methylpentanoic acid; trifluoroacetic acid
• Synonyms: N-[[4-(Imidazol-4-yl)methylamino]-2-(1-naphthyl)benzoyl]leucine trifluoroacetate salt

DATABASE IDS

• MDL Number: MFCD07776925
• PubChem SID: 24724491

PROPERTIES

• Empirical Formula (Hill Notation): C27H28N4O3 · C2HF3O2
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Gene Information: human ... FNTA(2339), PGGT1B(5229)
• Apperance: white solid
• Melting Point: 103-118.5 °C
• Solubility: DMSO: soluble25 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
GGTI-2133 is a cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I; IC50 = 38 nM) with a 140-fold selectivity over farnesyltransferase (FTase; IC50 = 5.4 μM).

Description (简体中文)

Biochem/physiol Actions
GGTI-2133 is a cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I; IC50 = 38 nM) with a 140-fold selectivity over farnesyltransferase (FTase; IC50 = 5.4 μM).