DAPT

• Catalog No.: D5942
• CAS Number: 208255-80-5
• M. F.: C23H26F2N2O4
• M. W.: 432.4603464
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: tert-butyl (2R)-2-[(2S)-2-[2-(3,5-difluorophenyl)acetamido]propanamido]-2-phenylacetate
• IUPAC Traditional name: tert-butyl (2R)-2-[(2S)-2-[2-(3,5-difluorophenyl)acetamido]propanamido]-2-phenylacetate
• Synonyms: LY-374973; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester

DATABASE IDS

• PubChem SID: 24893987
• CAS Number: 208255-80-5
• MDL Number: MFCD04974585

PROPERTIES

• Empirical Formula (Hill Notation): C23H26F2N2O4
• Purity: ≥98% (HPLC)
• Gene Information: human ... APH1A(51107), APH1B(83464), NCSTN(23385), NOTCH1(4851), NOTCH2(4853), NOTCH3(4854), NOTCH4(4855), PSEN1(5663), PSEN2(5664), PSENEN(55851)mouse ... Aph1a(226548), Aph1b(208117), Ncstn(59287), Notch1(18128), Notch2(18129), Notch3(18131), Notch4(18132), Psen1(19164), Psen2(19165), Psenen(66340)rat ... Aph1a(365872), Aph1b(300802), Ncstn(289231), Notch1(25496), Notch2(29492), Notch3(56761), Notch4(406162), Psen1(29192), Psen2(81751), Psenen(292788)
• Apperance: white solid
• Solubility: DMSO: ~18 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. As an inhibitor of Notch, DAPT may advance studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE). Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4.

Description (English)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. As an inhibitor of Notch, DAPT may advance studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE). Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4.