Efonidipine hydrochloride monoethanolate

• Catalog No.: E0159
• M. F.: C36H45ClN3O8P
• M. W.: 714.184561
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: ethanol 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ^5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate hydrochloride
• IUPAC Traditional name: efonidipine ethyl alcohol hydrochloride

DATABASE IDS

• MDL Number: MFCD00875717

PROPERTIES

• Empirical Formula (Hill Notation): C34H38N3O7P · HCl · C2H5OH
• Purity: ≥98% (HPLC)
• Apperance: pale yellow powder
• Solubility: DMSO: >5 mg/mL
• Solubility: H2O: insoluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(-)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.1

Description (简体中文)

Biochem/physiol Actions
Racemic efonidipine has both L-type and T-type calcium channel blocking activity. The R(-)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.1