GSK1016790A

• Catalog No.: G0798
• CAS Number: 942206-85-1
• M. F.: C28H32Cl2N4O6S2
• M. W.: 655.61288
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-[(2S)-1-{4-[(2S)-2-(2,4-dichlorobenzenesulfonamido)-3-hydroxypropanoyl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide
• IUPAC Traditional name: N-[(2S)-1-{4-[(2S)-2-(2,4-dichlorobenzenesulfonamido)-3-hydroxypropanoyl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide
• Synonyms: (N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide

DATABASE IDS

• CAS Number: 942206-85-1
• MDL Number: MFCD12912413

PROPERTIES

• Empirical Formula (Hill Notation): C28H32Cl2N4O6S2
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Solubility: DMSO: >10 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300 fold more potent than 4a-PDD (Cat. No. P8014).

Description (简体中文)

Biochem/physiol Actions
GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300 fold more potent than 4a-PDD (Cat. No. P8014).