Apicidin

• Catalog No.: A8851
• CAS Number: 183506-66-3
• M. F.: C34H49N5O6
• M. W.: 623.78276
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (3S,6S,15aR)-9-(butan-2-yl)-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)-tetradecahydro-1H-pyrido[1,2-a]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrone
• IUPAC Traditional name: (3S,6S,15aR)-6-[(1-methoxyindol-3-yl)methyl]-3-(6-oxooctyl)-9-(sec-butyl)-decahydro-2H-pyrido[1,2-a]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrone
• Synonyms: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]

DATABASE IDS

• MDL Number: MFCD03452661
• CAS Number: 183506-66-3

PROPERTIES

• Biological Source: from microbial
• Empirical Formula (Hill Notation): C34H49N5O6
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Apperance: solid
• Solubility: DMSO: ~1 mg/mL
• Solubility: acetonitrile: ~1 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H310-H330
• European Hazard Symbols: Highly toxic (T+)
• Personal Protective Equipment: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS Precautionary statements: P260-P264-P280-P284-P302 + P350-P310
• RID/ADR: UN 2811 6.1/PG 2
• Risk Statements: 26/27/28
• Safety Statements: 22-26-36/37/39-45
• Storage Temperature: -20°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 2
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Potent (nM) cell permeable inhibitor of histone deacetylase. Also, exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. In addition, it induces selective changes in the expression of p21 and gelsolin.

Description (简体中文)

Biochem/physiol Actions
Potent (nM) cell permeable inhibitor of histone deacetylase. Also, exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. In addition, it induces selective changes in the expression of p21 and gelsolin.