Ro 48-8071 fumarate

• Catalog No.: R2278
• CAS Number: 189197-69-1
• M. F.: C27H31BrFNO6
• M. W.: 564.4405432
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: but-2-enedioic acid; {6-[4-(4-bromobenzoyl)-3-fluorophenoxy]hexyl}(methyl)(prop-2-en-1-yl)amine
• IUPAC Traditional name: C23H27BrFNO2; butenedioic acid
• Synonyms: [4′-[6-(Allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate (1:1)

DATABASE IDS

• MDL Number: MFCD05865242
• CAS Number: 189197-69-1

PROPERTIES

• Empirical Formula (Hill Notation): C23H27NO2BrF · C4H4O4
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Melting Point: 90-92.7 °C
• Solubility: H2O: >5 mg/mL at ~60 °C
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Orally active 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop.

Description (简体中文)

Biochem/physiol Actions
Orally active 2,3-oxidosqualene:lanosterol cyclase (OSC) inhibitor. OSC (EC 5.4.99.7) represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop.