Y-27632 dihydrochloride

• Catalog No.: Y0503
• CAS Number: 129830-38-2
• M. F.: C14H25Cl2N3O2
• M. W.: 338.2732
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (1R,4r)-4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide hydrate dihydrochloride
• IUPAC Traditional name: (1R,4r)-4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide hydrate dihydrochloride
• Synonyms: (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride

DATABASE IDS

• MDL Number: MFCD03490488
• CAS Number: 129830-38-2
• PubChem SID: 24277699

PROPERTIES

• Empirical Formula (Hill Notation): C14H21N3O · 2HCl
• Purity: ≥98% (HPLC)
• Gene Information: human ... ROCK1(6093), ROCK2(9475)
• Apperance: white to beige powder
• Solubility: H2O: soluble14 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302 + H312 + H332
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 20/21/22
• Safety Statements: 36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Legal Information
Sold under license from Mitsubishi Pharma Corporation
Biochem/physiol Actions
Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.

Description (简体中文)

Legal Information
Sold under license from Mitsubishi Pharma Corporation
Biochem/physiol Actions
Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.