Vinorelbine ditartrate salt hydrate

• Catalog No.: V2264
• CAS Number: 125317-39-7(anhydrous)
• M. F.: C53H68N4O21
• M. W.: 1097.12122
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: bis((2R,3R)-2,3-dihydroxybutanedioic acid) hydrate methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(12S,14R)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^3,^1^1.0^4,^9]octadeca-3(11),4,6,8,15-pentaen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• IUPAC Traditional name: bis(L(+)-tartaric acid) vinorelbine hydrate
• Synonyms: 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt]; 5′-Noranhydrovinoblastine tartrate; KW-2307; NVB; Navelbine tartrate

DATABASE IDS

• CAS Number: 125317-39-7(anhydrous)
• PubChem SID: 24724660
• MDL Number: MFCD03613607

PROPERTIES

• Empirical Formula (Hill Notation): C45H54N4O8 · 2C4H6O6 · xH2O
• Purity: ≥98% (HPLC)
• Shipped in: wet ice
• Apperance: off-white powder
• Solubility: H2O: soluble10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H317
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS Precautionary statements: P280
• Risk Statements: 43
• Safety Statements: 26-36
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Vinorelbine is a potent anti-mitotic, anti-tumor agent. Vinorelbine inhibits microtubule assembly. Low neurotoxicity is related to its higher affinity for mitotic microtubules than for axonal microtubules.

Description (简体中文)

Biochem/physiol Actions
Vinorelbine is a potent anti-mitotic, anti-tumor agent. Vinorelbine inhibits microtubule assembly. Low neurotoxicity is related to its higher affinity for mitotic microtubules than for axonal microtubules.