5HPP-33

• Catalog No.: H9415
• CAS Number: 105624-86-0
• M. F.: C20H21NO3
• M. W.: 323.38564
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-[2,6-bis(propan-2-yl)phenyl]-5-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione
• IUPAC Traditional name: 2-(2,6-diisopropylphenyl)-5-hydroxyisoindole-1,3-dione
• Synonyms: 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione; 2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione

DATABASE IDS

• CAS Number: 105624-86-0
• MDL Number: MFCD03085294

PROPERTIES

• Empirical Formula (Hill Notation): C20H21NO3
• Purity: ≥98% (HPLC)
• Apperance: white to off-white solid
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H410
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P273-P501
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 50/53
• Safety Statements: 60-61
• Storage Temperature: 2-8°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).

Description (简体中文)

Biochem/physiol Actions
5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).