Penicillic acid

• Catalog No.: P0063
• CAS Number: 90-65-3
• M. F.: C8H10O4
• M. W.: 170.1626
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid
• IUPAC Traditional name: penicillic acid
• Synonyms: PA; 3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid

DATABASE IDS

• MDL Number: MFCD00004365
• CAS Number: 90-65-3
• EC Number: 202-008-1

PROPERTIES

• Empirical Formula (Hill Notation): C8H10O4
• Purity: ≥98% (HPLC)
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: ≤10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• RTECS: MM2625000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species. It is used to study FasL-induced apoptosis and cell viability in Burkitt′s lymphoma Raji cells1. It is used to study bacterial bioluminescence bioassays2 and genotoxicity of hepatocytes3.
Biochem/physiol Actions
Penicillic acid induces single and double strand DNA breaks. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme. It also inhibits muscle aldose dehydrogenase, alcohol dehydrogenase, and lactate dehydrogenase. Penicillic acid inhibits fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex1.
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species. It induces single and double strand DNA breaks. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme. It also inhibits muscle aldose dehydrogenase, alcohol dehydrogenase, and lactate dehydrogenase.

Description (简体中文)

Application
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species. It is used to study FasL-induced apoptosis and cell viability in Burkitt′s lymphoma Raji cells1. It is used to study bacterial bioluminescence bioassays2 and genotoxicity of hepatocytes3.
Biochem/physiol Actions
Penicillic acid induces single and double strand DNA breaks. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme. It also inhibits muscle aldose dehydrogenase, alcohol dehydrogenase, and lactate dehydrogenase. Penicillic acid inhibits fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex1.
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium species. It induces single and double strand DNA breaks. Penicillic acid irreversibly inhibits GDP-mannose dehydrogenase (DMG), an alginate synthesis enzyme. It also inhibits muscle aldose dehydrogenase, alcohol dehydrogenase, and lactate dehydrogenase.