Wogonin hydrate

• Catalog No.: W0769
• CAS Number: 632-85-9(anhydrous)
• M. F.: C16H14O6
• M. W.: 302.27876
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one hydrate
• IUPAC Traditional name: wogonin hydrate
• Synonyms: 5,7-Dihydroxy-8-methoxyflavone

DATABASE IDS

• MDL Number: MFCD12828871
• CAS Number: 632-85-9(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C16H12O5 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: ≥20 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: LK8331000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.

Description (简体中文)

Biochem/physiol Actions
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.