K-252a

• Catalog No.: K2015
• CAS Number: 99533-80-9
• M. F.: C27H21N3O5
• M. W.: 467.47274
• Purity: >98%

SYNONYMS

• IUPAC name: methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^1^5,^1^8.0^2,^6.0^7,^2^7.0^8,^1^3.0^1^9,^2^6.0^2^0,^2^5]octacosa-1(26),2(6),7(27),8,10,12,20(25),21,23-nonaene-16-carboxylate
• IUPAC Traditional name: methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^1^5,^1^8.0^2,^6.0^7,^2^7.0^8,^1^3.0^1^9,^2^6.0^2^0,^2^5]octacosa-1(26),2(6),7(27),8,10,12,20(25),21,23-nonaene-16-carboxylate

DATABASE IDS

• CAS Number: 99533-80-9
• MDL Number: MFCD00161522
• EC Number: 200-664-3

PROPERTIES

• Biological Source: from Nonomuraea longicatena
• Empirical Formula (Hill Notation): C27H21N3O5
• Purity: >98%
• Shipped in: dry ice
• Gene Information: human ... NTRK1(4914)rat ... Prkca(24680)
• Flash Point: 87 °C
• Flash Point: 188.6 °F
• Personal Protective Equipment: Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• Storage Temperature: -20°C
• German water hazard class: 1

DETAILS

Description (English)

Physical form
Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).
Biochem/physiol Actions
K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor.1 At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures.2 K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c.3 K-252a improves psoriasis in a SCID mouse-human skin model4 and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.5

Description (简体中文)

Physical form
Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).
Biochem/physiol Actions
K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor.1 At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures.2 K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c.3 K-252a improves psoriasis in a SCID mouse-human skin model4 and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.5