Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt

• Catalog No.: B6684
• CAS Number: 185246-32-6
• M. F.: C18H16BrN5NaO7PS
• M. W.: 580.281471
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: sodium (2R,4aR,6R,7R,7aS)-6-{2-bromo-9-oxo-6-phenyl-3H,4H,9H-imidazo[1,2-a]purin-3-yl}-7-hydroxy-2-sulfanylidene-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate hydrate
• IUPAC Traditional name: sodium (2R,4aR,6R,7R,7aS)-6-{2-bromo-9-oxo-6-phenyl-4H-imidazo[1,2-a]purin-3-yl}-7-hydroxy-2-sulfanylidene-tetrahydro-4H-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate hydrate
• Synonyms: Rp-8-Br-PET-cGMPS; Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3′,5′-cyclic monophosphorothioate sodium salt

DATABASE IDS

• PubChem SID: 24724424
• CAS Number: 185246-32-6

PROPERTIES

• Empirical Formula (Hill Notation): C18H14BrN5NaO6PS
• Purity: ≥98% (HPLC)
• Apperance: white to beige powder
• Melting Point: 240-300 °C(lit.)
• Solubility: H2O: soluble15 mg/mL at ≤60 °C
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Condition: desiccated
• Storage Condition: under inert gas
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Packaging
Hygroscopic, store under argon
Legal Information
U.S. Patent 5,625,056, DE Patent 4,217,679.
Biochem/physiol Actions
Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki = 30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50 = 25 micromoles).

Description (简体中文)

包装
Hygroscopic, store under argon
Legal Information
U.S. Patent 5,625,056, DE Patent 4,217,679.
Biochem/physiol Actions
Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki = 30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50 = 25 micromoles).