Rebamipide hydrate

• Catalog No.: R5655
• CAS Number: 90098-04-7(anhydrous)
• M. F.: C19H17ClN2O5
• M. W.: 388.80168
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-[(4-chlorophenyl)formamido]-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid hydrate
• IUPAC Traditional name: rebamipide hydrate
• Synonyms: OPC 12759 hydrate; Proamipide hydrate; α-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic acid hydrate; Mucosta hydrate

DATABASE IDS

• MDL Number: MFCD11114396
• CAS Number: 90098-04-7(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C19H15ClN2O4 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: white powder
• Solubility: DMSO: >5 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• GHS Precautionary statements: P301 + P310
• RTECS: VC2518500
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Rebamipide is an anti-ulcer agent with free-radical scavenging and anti-inflammatory effects. It has been used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating COX-2 genes. Rebamipide significantly reduced ulcerogenesis and maintained mucosal superoxide dismutase (SOD) activity. It has also been used for the treatment of Behçet′s disease. Rebamipide may be involved in a noval mechanism to enhance tear secretion and increase mucin levels covering conjunctiva and cornea.

Description (简体中文)

Biochem/physiol Actions
Rebamipide is an anti-ulcer agent with free-radical scavenging and anti-inflammatory effects. It has been used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating COX-2 genes. Rebamipide significantly reduced ulcerogenesis and maintained mucosal superoxide dismutase (SOD) activity. It has also been used for the treatment of Behçet′s disease. Rebamipide may be involved in a noval mechanism to enhance tear secretion and increase mucin levels covering conjunctiva and cornea.