QS11 hydrate

• Catalog No.: Q4972
• CAS Number: 944328-88-5(anhydrous)
• M. F.: C36H35N5O3
• M. W.: 585.6948
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2S)-2-{[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]-9H-purin-6-yl]amino}-3-phenylpropan-1-ol hydrate
• IUPAC Traditional name: (2S)-2-{[2-(2,3-dihydro-1H-inden-5-yloxy)-9-[(4-phenylphenyl)methyl]purin-6-yl]amino}-3-phenylpropan-1-ol hydrate
• Synonyms: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate

DATABASE IDS

• CAS Number: 944328-88-5(anhydrous)
• MDL Number: MFCD12912439

PROPERTIES

• Empirical Formula (Hill Notation): C36H33N5O2 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: white powder
• Solubility: DMSO: >10 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell morphology, motility, proliferation, and differentiation during development. The GTPase activating protein of ADP-ribosylation factors (ARFGAPs) regulates the small GTPase ADP-ribosylation factors (ARFs) that mediate a number of biological processes, including vesicle trafficking and cytoskeleton reorganization. QS-11 binds and inhibits GTPase activating protein of ADP-ribosylation factor1 (ARFGAP1). Inhibition of ARFGAPs increases the level of activated ARF and subsequent β-catenin translocation leading to pathway activation.

Description (简体中文)

Biochem/physiol Actions
QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1), as well as a synergizer of the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway regulates cell morphology, motility, proliferation, and differentiation during development. The GTPase activating protein of ADP-ribosylation factors (ARFGAPs) regulates the small GTPase ADP-ribosylation factors (ARFs) that mediate a number of biological processes, including vesicle trafficking and cytoskeleton reorganization. QS-11 binds and inhibits GTPase activating protein of ADP-ribosylation factor1 (ARFGAP1). Inhibition of ARFGAPs increases the level of activated ARF and subsequent β-catenin translocation leading to pathway activation.