PAC-1

• Catalog No.: P0115
• CAS Number: 315183-21-2
• M. F.: C23H28N4O2
• M. W.: 392.49402
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-(4-benzylpiperazin-1-yl)-N'-{[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
• IUPAC Traditional name: 2-(4-benzylpiperazin-1-yl)-N'-{[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
• Synonyms: 1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide; (4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide

DATABASE IDS

• CAS Number: 315183-21-2
• MDL Number: MFCD03302441

PROPERTIES

• Empirical Formula (Hill Notation): C23H28N4O2
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Solubility: DMSO: ≥10 mg/mL
• Solubility: deionized water: ≤2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335-H400
• European Hazard Symbols: Harmful (Xn)
• European Hazard Symbols: Nature polluting (N)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P273-P305 + P351 + P338
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 22-36/37/38-50/53
• Safety Statements: 26-36/37-60-61
• Storage Temperature: room temp
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.

Description (简体中文)

Biochem/physiol Actions
PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.