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PAC-1_Molecular_structure_CAS_315183-21-2)
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PAC-1

Catalog No. P0115 Name Sigma Aldrich
CAS Number 315183-21-2 Website http://www.sigmaaldrich.com
M. F. C23H28N4O2 Telephone 1-800-521-8956
M. W. 392.49402 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 73221

SYNONYMS

IUPAC name
2-(4-benzylpiperazin-1-yl)-N'-{[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
IUPAC Traditional name
2-(4-benzylpiperazin-1-yl)-N'-{[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
Synonyms
1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide
(4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide

DATABASE IDS

CAS Number 315183-21-2
MDL Number MFCD03302441

PROPERTIES

Empirical Formula (Hill Notation) C23H28N4O2
Purity ≥98% (HPLC)
Apperance white solid
Solubility DMSO: ≥10 mg/mL
Solubility deionized water: ≤2 mg/mL
GHS Pictograms GHS07
GHS Pictograms GHS09
GHS Signal Word Warning
GHS Hazard statements H302-H315-H319-H335-H400
European Hazard Symbols Harmful Harmful (Xn)
European Hazard Symbols Nature polluting Nature polluting (N)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P261-P273-P305 + P351 + P338
RID/ADR UN 3077 9/PG 3
Risk Statements 22-36/37/38-50/53
Safety Statements 26-36/37-60-61
Storage Temperature room temp
Hazard Class 9
UN Number 3077
Packing Group 3
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
Description (简体中文)
Biochem/physiol Actions
PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.

REFERENCES