Metyrapone

• Catalog No.: M2696
• CAS Number: 54-36-4
• M. F.: C14H14N2O
• M. W.: 226.27376
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-methyl-1,2-bis(pyridin-3-yl)propan-1-one
• IUPAC Traditional name: metyrapone
• Synonyms: 2-甲基-1,2-二-3-吡啶基-1-丙酮; 美替拉酮; 2-Methyl-1,2-di-3-pyridyl-1-propanone; Su-4885; Metyrapone

DATABASE IDS

• Beilstein Number: 163023
• CAS Number: 54-36-4
• EC Number: 200-206-2
• MDL Number: MFCD00006397

PROPERTIES

• Empirical Formula (Hill Notation): C14H14N2O
• Purity: ≥98% (HPLC)
• Apperance: solid
• Flash Point: >110 °C
• Flash Point: >230 °F
• Melting Point: 52-55 °C(lit.)
• Solubility: H2O: <2 mg/mL
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• RTECS: UC3050000
• Safety Statements: 26
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.

Description (简体中文)

Biochem/physiol Actions
Metyrapone is a glucocorticoid synthesis inhibitor; a standard in assessing adrenal gland function especially in response to stress, as well as pituitary gland function. In addition to acting as a glucocorticoid synthesis inhibitor, Metyrapone also inhibits cytochrome P450-mediated prostaglandin ω/ω-1 hydroxylase activity and impairs learning and memory. Data shows results in activation of the sleep EEG and a robust decrease in quantitative delta sleep.