RP-107

• Catalog No.: R3405
• CAS Number: 496864-15-4
• M. F.: C16H17N3O
• M. W.: 267.32568
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
• IUPAC Traditional name: 4-{7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl}phenol
• Synonyms: 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine

DATABASE IDS

• CAS Number: 496864-15-4
• MDL Number: MFCD04973541

PROPERTIES

• Empirical Formula (Hill Notation): C16H17N3O
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335-H413
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36/37
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC50 = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

Description (简体中文)

Biochem/physiol Actions
RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC50 = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.