AD 198

• Catalog No.: A9481
• CAS Number: 98983-21-2
• M. F.: C39H43NO12
• M. W.: 717.75822
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-[(2S,4S)-4-{[(2R,4S,5S,6S)-4-(benzylamino)-5-hydroxy-6-methyloxan-2-yl]oxy}-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl]-2-oxoethyl pentanoate
• IUPAC Traditional name: 2-[(2S,4S)-4-{[(2R,4S,5S,6S)-4-(benzylamino)-5-hydroxy-6-methyloxan-2-yl]oxy}-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-oxoethyl pentanoate
• Synonyms: N-Benzyladriamycin-14-valerate

DATABASE IDS

• CAS Number: 98983-21-2

PROPERTIES

• Empirical Formula (Hill Notation): C39H43NO12
• Purity: ≥98% (HPLC)
• Apperance: red solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: insoluble
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS: SA3697000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
AD 198 is a PKC-delta activator. Phospholipid scramblase 3 (PLS3) is an enzyme that plays a critical role in mitochondrial morphology, functions, and apoptotic response. During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitochondria and phosphorylates PLS3. Used to show that PLS3 is a critical downstream effector of PKC-delta in AD 198-induced apoptosis.

Description (简体中文)

Biochem/physiol Actions
AD 198 is a PKC-delta activator. Phospholipid scramblase 3 (PLS3) is an enzyme that plays a critical role in mitochondrial morphology, functions, and apoptotic response. During apoptosis, activated protein kinase C-delta (PKC-delta) translocates to mitochondria and phosphorylates PLS3. Used to show that PLS3 is a critical downstream effector of PKC-delta in AD 198-induced apoptosis.