CHPG

• Catalog No.: C7743
• CAS Number: 170846-74-9
• M. F.: C8H8ClNO3
• M. W.: 201.60702
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
• IUPAC Traditional name: amino(2-chloro-5-hydroxyphenyl)acetic acid
• Synonyms: α-amino-2-chloro-5-hydroxybenzeneacetic acid; (RS)-2-Chloro-5-hydroxyphenylglycine; (RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid

DATABASE IDS

• CAS Number: 170846-74-9
• MDL Number: MFCD01321059

PROPERTIES

• Empirical Formula (Hill Notation): C8H8ClNO3
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Apperance: white solid
• Solubility: DMSO: ≥10 mg/mL
• Solubility: H2O: insoluble
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
CHPG is a selective, potent mGluR5 agonist. CHO cells expressing mGluR5 (but not those expressing mGluR1) are activated by CHPG. In vivo, CHPG stimulates thalamic neurons and is antagonized by MPEP (selective mGluR5 antagonist); CHPG potentiates NMDA and AMPA responses in spinal cord and produces oscillations in intracellular calcium in dorsal root ganglion cells.

Description (简体中文)

Biochem/physiol Actions
CHPG is a selective, potent mGluR5 agonist. CHO cells expressing mGluR5 (but not those expressing mGluR1) are activated by CHPG. In vivo, CHPG stimulates thalamic neurons and is antagonized by MPEP (selective mGluR5 antagonist); CHPG potentiates NMDA and AMPA responses in spinal cord and produces oscillations in intracellular calcium in dorsal root ganglion cells.