Azelnidipine

• Catalog No.: A7106
• CAS Number: 123524-52-7
• M. F.: C33H34N4O6
• M. W.: 582.64626
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-[1-(diphenylmethyl)azetidin-3-yl] 5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: azelnidipine
• Synonyms: CS-905; 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester; RS-9054; 2-Amino-1,4-dihydro-6-methyl-4-(3 nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester; Calblock

DATABASE IDS

• MDL Number: MFCD00865803
• CAS Number: 123524-52-7

PROPERTIES

• Empirical Formula (Hill Notation): C33H34N4O6
• Purity: ≥98% (HPLC)
• Apperance: powder
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H318
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 22-41
• RTECS: US7968332
• Safety Statements: 26-39
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Application
Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Acute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis.
Biochem/physiol Actions
Azelnidipine, a novel dihydropyridine derivative, is a L-type calcium channel blocker and antihypertensive. Unlike other L-type calcium channel blockers, azelnidipine causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. Azelnidipine may have a protective role in inflammation in atherosclerosis.

Description (简体中文)

Application
Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Acute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis.
Biochem/physiol Actions
Azelnidipine, a novel dihydropyridine derivative, is a L-type calcium channel blocker and antihypertensive. Unlike other L-type calcium channel blockers, azelnidipine causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. Azelnidipine may have a protective role in inflammation in atherosclerosis.