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Azelnidipine

Catalog No. A7106 Name Sigma Aldrich
CAS Number 123524-52-7 Website http://www.sigmaaldrich.com
M. F. C33H34N4O6 Telephone 1-800-521-8956
M. W. 582.64626 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154044

SYNONYMS

IUPAC name
3-[1-(diphenylmethyl)azetidin-3-yl] 5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
IUPAC Traditional name
azelnidipine
Synonyms
CS-905
2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester
RS-9054
2-Amino-1,4-dihydro-6-methyl-4-(3 nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester
Calblock

DATABASE IDS

MDL Number MFCD00865803
CAS Number 123524-52-7

PROPERTIES

Empirical Formula (Hill Notation) C33H34N4O6
Purity ≥98% (HPLC)
Apperance powder
Solubility DMSO: >10 mg/mL
GHS Pictograms GHS05
GHS Pictograms GHS07
GHS Signal Word Danger
GHS Hazard statements H302-H318
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements P280-P305 + P351 + P338
Risk Statements 22-41
RTECS US7968332
Safety Statements 26-39
Storage Temperature room temp
German water hazard class 3

DETAILS

Description (English)
Application
Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Acute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis.
Biochem/physiol Actions
Azelnidipine, a novel dihydropyridine derivative, is a L-type calcium channel blocker and antihypertensive. Unlike other L-type calcium channel blockers, azelnidipine causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. Azelnidipine may have a protective role in inflammation in atherosclerosis.
Description (简体中文)
Application
Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Acute administration of azelnidipine prevents a sudden drop of cardiac function after acute stress. Azelnidipine may have a protective role in inflammation associated with atherosclerosis.
Biochem/physiol Actions
Azelnidipine, a novel dihydropyridine derivative, is a L-type calcium channel blocker and antihypertensive. Unlike other L-type calcium channel blockers, azelnidipine causes minimal stimulation of the sympathetic nervous system despite its significant depressor effect. Azelnidipine may have a protective role in inflammation in atherosclerosis.

REFERENCES