III-31-C

• Catalog No.: C0619
• CAS Number: 398515-96-3
• M. F.: C35H52N4O7
• M. W.: 640.80998
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: methyl (2S)-2-[(2S)-2-({benzyl[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-4-phenylbutyl]carbamoyl}amino)-4-methylpentanamido]-3-methylbutanoate
• IUPAC Traditional name: methyl (2S)-2-[(2S)-2-({benzyl[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl]carbamoyl}amino)-4-methylpentanamido]-3-methylbutanoate
• Synonyms: N-[[[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-4-phenylbutyl](phenylmethyl)amino]carbonyl]-L-leucyl-L-valine methyl ester; WPE-III-31-C

DATABASE IDS

• CAS Number: 398515-96-3

PROPERTIES

• Empirical Formula (Hill Notation): C35H52N4O7
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: ≥9 mg/mL
• Personal Protective Equipment: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• Storage Condition: desiccated
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor that binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors that affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.

Description (简体中文)

Biochem/physiol Actions
III-31-C is a (hydroxyethyl)urea γ-secretase inhibitor that binds to γ-secretase at the substrate docking site. DAPT, also a γ-secretase inhibitor binds to the substrate docking site as well. III-31-C is useful for the affinity isolation and characterization of the protease complex and for testing other ihhibitors that affect the γ-secretase active site. The γ-secretase complex is composed of presenilin as a catalytic component and three integral membrane proteins, nicastrin, Aph-1 and Pen-2.