Pirarubicin

• Catalog No.: P8624
• CAS Number: 72496-41-4
• M. F.: C32H37NO12
• M. W.: 627.63568
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
• IUPAC Traditional name: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
• Synonyms: THP

DATABASE IDS

• CAS Number: 72496-41-4
• MDL Number: MFCD00869742

PROPERTIES

• Empirical Formula (Hill Notation): C32H37NO12
• Purity: ≥95% (HPLC)
• Shipped in: wet ice
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Anthracycline antibiotic that is an analog of doxorubicin. Antineoplastic. Pirarubicin is transported into cells vial a sodium-dependent nucleoside transporter.1,2 It is used to intercalate DNA and inhibit the activity of topoisomerase II and induce DNA crosslinking.
Application
Pirarubicin, an anthracycline antibiotic, is an anticancer drug. Pirarubicin is used to study synergistic cytotoxicity and apoptosis of cancer cells1,2. It is used to study how to protect multi-drug resistance cells from anthracycline induced cytotoxicity3.

Description (简体中文)

Biochem/physiol Actions
Anthracycline antibiotic that is an analog of doxorubicin. Antineoplastic. Pirarubicin is transported into cells vial a sodium-dependent nucleoside transporter.1,2 It is used to intercalate DNA and inhibit the activity of topoisomerase II and induce DNA crosslinking.
Application
Pirarubicin, an anthracycline antibiotic, is an anticancer drug. Pirarubicin is used to study synergistic cytotoxicity and apoptosis of cancer cells1,2. It is used to study how to protect multi-drug resistance cells from anthracycline induced cytotoxicity3.