N-Methylhistaprodifen dioxalate salt

• Catalog No.: M7320
• CAS Number: 270079-48-6
• M. F.: C25H29N3O8
• M. W.: 499.51306
• Purity: ≥98% (HPLC)

SYNONYMS

• Title: N-methylhistaprodifen 二草酸盐
• IUPAC name: bis(oxalic acid); {2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethyl}(methyl)amine
• IUPAC Traditional name: bis(oxalic acid); {2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethyl}(methyl)amine
• Synonyms: N-Methyl-2-[2-(3,3-diphenylpropyl)-1H-imidazol -4-yl]-ethanamine 二草酸盐; N-Methyl-2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]-ethanamine dioxalate salt

DATABASE IDS

• MDL Number: MFCD09752603
• CAS Number: 270079-48-6

PROPERTIES

• Empirical Formula (Hill Notation): C21H25N3 · 2 C2H2O4
• Purity: ≥98% (HPLC)
• Apperance: white solid
• Solubility: DMSO: ≥10 mg/mL
• Solubility: H2O: insoluble <2 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
N-Methylhistaprodifen is more potent than histamine by a factor of 3.5 on guinea pig ileum; more potent than histamine by a factor of 4.3 on guinea pig arterial H1-receptor-mediated vasoconstriction; most potent H1-receptor agonist on the guinea pig ileum out of 17 agonists tested. pEC50 = 7.24 in contraction of guinea pig ileal whole segments; pEC50 = 6.31 in contraction of guinea pig aortic segments. N-methylhistaprodifen does not stimulate H2 and H3 histamine receptors; potential use in the study of H1-receptor-mediated physiological and pathophysiological functions.

Description (简体中文)

Biochem/physiol Actions
N-Methylhistaprodifen is more potent than histamine by a factor of 3.5 on guinea pig ileum; more potent than histamine by a factor of 4.3 on guinea pig arterial H1-receptor-mediated vasoconstriction; most potent H1-receptor agonist on the guinea pig ileum out of 17 agonists tested. pEC50 = 7.24 in contraction of guinea pig ileal whole segments; pEC50 = 6.31 in contraction of guinea pig aortic segments. N-methylhistaprodifen does not stimulate H2 and H3 histamine receptors; potential use in the study of H1-receptor-mediated physiological and pathophysiological functions.