Brefeldin A

• Catalog No.: B5936
• CAS Number: 20350-15-6
• M. F.: C16H24O4
• M. W.: 280.35936

SYNONYMS

• IUPAC name: (1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
• IUPAC Traditional name: brefeldin A
• Synonyms: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone; Ascotoxin; Cyanein; Decumbin; BFA

DATABASE IDS

• MDL Number: MFCD12913297
• Beilstein Number: 25191
• CAS Number: 20350-15-6

PROPERTIES

• Biological Source: from Penicillium brefeldianum
• Concentration: 10 mg/mL in DMSO
• Empirical Formula (Hill Notation): C16H24O4
• Shipped in: wet ice
• Sterility: 0.2 μm filtered
• Flash Point: 87 °C
• Flash Point: 188.6 °F
• Personal Protective Equipment: Eyeshields, Faceshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Application
Brefeldin A is produced from Penicillium brefeldianum and is used to study protein transport.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. 1 BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

Description (简体中文)

Application
Brefeldin A is produced from Penicillium brefeldianum and is used to study protein transport.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus by inhibiting transport of proteins from ER to Golgi and inducing retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum. 1 BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.