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Cytochalasin D

Catalog No. C2618 Name Sigma Aldrich
CAS Number 22144-77-0 Website http://www.sigmaaldrich.com
M. F. C30H37NO6 Telephone 1-800-521-8956
M. W. 507.61788 Fax
Purity Email
Storage Chembase ID: 126841

SYNONYMS

Title
细胞松弛素 D
IUPAC name
(3S,4S,6S,6aR,10S,12R,15R,15aR,15bR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylidene-1,11-dioxo-1H,2H,3H,4H,5H,6H,6aH,9H,10H,11H,12H,15H,15bH-cycloundeca[e]isoindol-15-yl acetate
IUPAC Traditional name
cytochalasin D
Synonyms
Zygosporin A
松胞菌素 D

DATABASE IDS

MDL Number MFCD00077706
CAS Number 22144-77-0
Beilstein Number 1632828

PROPERTIES

Biological Source from Zygosporium mansonii
Concentration 5 mg/mL in DMSO
Empirical Formula (Hill Notation) C30H37NO6
Quality Level PREMIUM
Shipped in wet ice
Sterility 0.2 μm filtered
Flash Point 87 °C
Flash Point 188.6 °F
MSDS Link Download
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Storage Temperature -20°C
German water hazard class 2

DETAILS

Description (English)
Biochem/physiol Actions
Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.
Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Cytochalasin B is a cell permeable fungal toxin and potent inhibitor of actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It inhibits smooth muscle contraction and insulin-stimulated, but not basal, transport of glucose.
Application
Cytochalasin B is used to inhibit sugar transport in fibroblasts 1, decrease cytoskeletal actin and myosin in rabbit neutrophils 2, and to stimulate B lymphocytes 3. It is a potent inhibitor of actin polymerization, disrupts actin microfilaments, activates the p53-dependent pathways, inhibits smooth muscle contraction, and inhibits insulin-stimulated glucose transport.
Description (简体中文)
Biochem/physiol Actions
肌动蛋白聚合化的强效抑制剂;破坏肌动蛋白微丝;活化 p53 依赖性途径;抑制平滑肌收缩;抑制胰岛素刺激的糖转运。
Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
Cytochalasin B is a cell permeable fungal toxin and potent inhibitor of actin polymerization. It disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. It inhibits smooth muscle contraction and insulin-stimulated, but not basal, transport of glucose.
Application
Cytochalasin B is used to inhibit sugar transport in fibroblasts 1, decrease cytoskeletal actin and myosin in rabbit neutrophils 2, and to stimulate B lymphocytes 3. It is a potent inhibitor of actin polymerization, disrupts actin microfilaments, activates the p53-dependent pathways, inhibits smooth muscle contraction, and inhibits insulin-stimulated glucose transport.

REFERENCES